Research

Full-thickness Macular Hole Closure with Topical Medical Therapy

Purpose: To examine the efficacy and clinical characteristics of successful full-thickness macular hole closure with topical therapy. Methods: Retrospective case series of full-thickness macular holes managed by...

Ten-year Longitudinal Morphologic Changes in Dome-shaped Maculas in Hıghly Myopic Eyes

Purpose: To determine the longitudinal changes in the morphologic features of dome-shaped macula in highly myopic eyes. Methods: Patients with a dome-shaped macula and high myopia (spherical...

From Drusen to Type 3 Macular Neovascularization

Purpose: To investigate the imaging features preceding the occurrence of type 3 (T3) macular neovascularization (MNV) using tracked spectral-domain optical coherence tomography (SD-OCT). Method: From a cohort...

Risk of Exudation in Eyes with Non-exudative Polypoidal Choroidal Vasculopathy

Purpose: To investigate the characteristics and natural history of treatment-naïve non-exudative polypoidal choroidal vasculopathy (PCV) and to determine biomarkers predicting exudative conversion. Methods: Patients diagnosed with non-exudative PCV based on indocyanine green angiography (ICGA) and optical coherence...

Morphological Characteristics and Progression Patterns of Macular Neovascularization-related Atrophy in Eyes with Pathologic Myopia

Purpose: To investigate the development and progression patterns of macular neovascularization (MNV)-related atrophies in eyes with pathologic myopia (PM). Methods: Twenty-seven eyes of 26 patients with MNV followed from its onset to progression to macular...

Long-term Progression Pattern of Myopic Tractional Maculopathy: Outcomes and Risk Factors

Purpose: To evaluate the long-term progression pattern of myopic tractional maculopathy and the risk factors. Methods: The prevalence and grade of myopic tractional maculopathy were assessed with optical coherence tomography at enrollment and at the 2-year follow-up....

Enlargement of Choroidal Neovascularizatıon before Recurrence after Photodynamic Therapy for Pachychoroid Neovasculopathy

Purpose: To investigate predictors of recurrent exudation in choroidal neovascularization (CNV) of pachychoroid neovasculopathy (PNV) after photodynamic therapy (PDT). Methods: Consecutive, treatment-naïve, symptomatic patients with PNV with subfoveal retinal fluid (SRF) treated with PDT and followed for...

Photobiomodulation therapy for large soft drusen and drusenoid pigment epithelial detachment in age-related macular degeneration: a single-center prospective pilot study

Purpose: To evaluate visual acuity and morphologic changes after photobiomodulation (PBM) for patients affected with large soft drusen and/or drusenoid pigment epithelial detachment (dPED) associated to dry age-related macular degeneration (AMD). Method: Twenty eyes with...

Subretinal Fluid Associated with Drusenoid Pigment Epithelial Detachment

Purpose: To analyze the clinical characteristics of drusenoid pigment epithelial detachment (PED) with subretinal fluid (SRF) and to evaluate the impact of SRF on the long-term visual and anatomical outcomes. Methods: Forty-seven eyes with drusenoid...

Increasing Evidence for the Safety of Fovea-Involving Half-dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Purpose: A retrospective study was performed with data from the prospective randomized controlled trials, PLACE and SPECTRA, assessing the risk of foveal atrophy and the likelihood of structural and functional improvement on optical coherence tomography,...

Predisposing characteristics of optical coherence tomography for patients with persistent subretinal fluid after successful repair of rhegmatogenous retinal detachment

Purpose: To investigate the predisposing clinical parameters and characteristics of fundus imaging of patients with persistent subretinal fluid (PSF) after successful repair of rhegmatogenous retinal detachment. Methods: A retrospective study recruiting 57 patients was conducted....

Use of Optical Coherence Tomography in Detecting Retinal Tears in Acute, Symptomatic Posterior Vitreous Detachment

Purpose: To evaluate the association of posterior vitreous opacities (PVO) on optical coherence tomography (OCT) with retinal tears identified on exam, in patients with acute, symptomatic posterior vitreous detachment (PVD). Method: Data was retrospectively collected...

Focal Choroidal Thickness Hemodynamıcs as a Sign of Macular Neovascularizatıon Activity in Pathologic Myopia

Purpose: To analyze the relationship between a focal increase of choroidal thickness (ChT) and exudative activity of macular neovascularization (MNV) secondary to pathologic myopia. Methods: Retrospective analysis including eyes with pathologic myopia presenting with a focally increased...

Combined Hamartoma of the Retina and Retinal Pigment Epithelium at Pediatric Age: Surgical versus Conservative Approach

Purpose: To report outcomes of pediatric patients with combined hamartoma of the retina and the retina pigment epithelium (CHRRPE) followed up conservatively or after pars plana vitrectomy (PPV). Methods: This retrospective multicenter study included sixty-two...

Conventional internal limiting membrane peeling versus inverted flap for small-to-medium idiopathic macular hole: a randomized trial

Purpose: To compare conventional internal limiting membrane (ILM) peeling versus inverted flap technique in small-to-medium idiopathic macular hole. Methods: Eyes with ≤400 microns Idiopathic macular holes were randomized into the conventional ILM peeling group (25 eyes) and...

Effect of Oral Carbonic Anhydrase İnhibitor on Cystoid Macular Edema Associated with Retinitis Pigmentosa: An OCT and OCT Angiography Study

Purpose: To investigate the factors associated with visual improvement in response to oral carbonic anhydrase inhibitors (CAIs) and the occurrence of microvascular changes in patients with retinitis pigmentosa-associated cystoid macular edema (RP-CME). Methods: This retrospective cohort study...

Imaging the vitreous with a Novel Boosted Optical Coherence Tomography Technique: Vitreous Degeneration and Cisterns

Purpose: To evaluate the degenerative findings including cistern formation in the premacular vitreous using optical coherence tomography. Methods: A novel enhanced vitreous imaging method by which four A-scans at each position were averaged before the...

Pars Plana Vitrectomy with and without ILM-peeling for Diabetic Patients with Macula Involved Tractional Retinal Detachment

Purpose: To evaluate the effect of internal limiting membrane (ILM) peeling on anatomical and functional results in pars plana vitrectomy (PPV) performed eyes with tractional retinal detachment affecting the macula due to diabetes mellitus (DM). Methods: Patients...

Predictive factors of spontaneous release of vitreomacular traction: a systematic review and meta-analysis

Purpose: To review predictive factors of spontaneous vitreomacular traction (VMT) release. Methods: A systematic literature search was performed on Ovid MEDLINE, Embase, and Cochrane Library. Studies comparing spontaneously released VMT to persistent VMT were included....

Differences in long-term progression of atrophy between neovascular and non-neovascular age-related macular degeneration

Purpose: To compare enlargement rates over 5 years of follow-up in geographic atrophy (GA) versus macular atrophy (MA) associated with macular neovascularization (MNV). Design: Retrospective, longitudinal comparative case series of age-related macular degeneration (AMD)...

Efficacy of Half-Dose Photodynamic Therapy Versus High-Density Subthreshold Micropulse Laser for Treating Pigment Epithelial Detachments in Chronic Central Serous Chorioretinopathy

Purpose: Comparing the effect of half-dose photodynamic therapy and high-density subthreshold micropulse laser treatment on retinal pigment epithelial detachments (PEDs) in chronic central serous chorioretinopathy. Methods: This study included data from the PLACE trial, a...

Predictors of Retinal Pigment Epithelium Tear Development After Treatment for Neovascular Age-Related Macular Degeneration Usıng Swept-Source Optical Coherence Tomography Angiography

Purpose: To investigate the predictors of retinal pigment epithelium (RPE) tear development after treatment for neovascular age-related macular degeneration (AMD) using swept-source optical coherence tomography angiography (OCTA). Methods: This prospective study included 152 treatment-naïve eyes...

Hyperreflective foci as important prognostic indicators of progression of retınitis pigmentosa

Purpose: To investigate the presence and clinical relevance of hyperreflective foci (HRFs) in retinitis pigmentosa. Methods: Seventy seven retinitis pigmentosa cases were retrospectively reviewed. The 10-mm wide cross-line macular scans in optical coherence tomography were acquired. Hyperreflective...

Peripapillary pachychoroid syndrome: New Insights

Purpose: Available literature on peripapillary pachychoroid syndrome (PPS) is very limited. The purpose of this study is to evaluate features of PPS using multimodal imaging and shed further light on this entity. Methods: This is...

Correlation between focal choroidal excavation and underlying retinochoroidal disease: A pathological hypothesis from clinical observation

Purpose: To evaluate focal choroidal excavation (FCE) in eyes with various diseases using multimodal imaging modalities and to investigate the correlation of FCE and underlying chorioretinal diseases. Methods: This retrospective observational study included 62 eyes from...

Utilizatıon of Spectral Domain Optical Coherence Tomography to Identify Posterior Vitreous Detachment in Patients with Retinal Detachment

Purpose: To compare posterior vitreous detachment (PVD) identification rate between clinical examination versus spectral domain optical coherence tomography in patients with retinal detachment (RD). Methods: Data from the Primary Retinal Detachment Outcomes Study were used for this...

Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography

Objective: The aim of this study was to evaluate the perifoveal and peripapillary microvascular structure in patients with Behçet's disease (BD) without clinically ocular involvement. Methods: Fifty-six eyes of 28 patients with Behçet's disease without clinically ocular...

Evaluation of the Effects of Silicone Oil on the Macula with Optical Coherence Tomography in Patients with Rhegmatogenous Retinal Detachment

Objectives: The effects of silicone endotamponade duration on the macula were evaluated in patients with rhegmatogenous retinal detachment. Materials and Methods: Sixty-five eyes of 65 cases with rhegmatogenous retinal detachment that underwent pars plana vitrectomy...

Microcystic Macular Edema and Cystoid Macular Edema Before and After Epiretinal Membrane Surgery

Purpose: To investigate the types of intraretinal cysts (IRCs) that are associated with epiretinal membranes (ERMs) and to evaluate the effects of each type of IRC on postoperative outcomes. Methods: Retrospective, cross-sectional study design. Patients who underwent...

Evaluation of Retinal Vessel Diameters in Eyes With Active Central Serous Chorioretinopathy

Purpose: To compare the retinal vessel diameters of healthy eyes and active central serous chorioretinopathy (CSC) eyes, and to evaluate possible effect of retinal vessel diameter alterations on the pathogenesis of CSC. Methods: This retrospective...

Optical coherence tomography biomarkers for reduction of drusenoid pigment epithelium detachment

Purpose: To identify the optical coherence tomography biomarkers that can collectively predict the probability of collapse or reduction of drusenoid pigment epithelium detachment (PED). Methods: This consecutive observational case series reviewed the clinical data of 24 eyes...

The Pigtail Sign: A New OCT Finding After Inverted ILM Flap Surgery for Idiopathic Macular Hole

Purpose: To report a new spectral domain optical coherence tomography (OCT) finding called the pigtail sign. It was found during follow-up of idiopathic macular hole cases after inverted internal limiting membrane (ILM) flap surgery. Methods: This is...

Assessing the long-term evolution of type 3 neovascularization in age-related macular degeneration using optical coherence tomography angiography

Purpose:  To analyze the evolution of type 3 neovascularization in eyes with age-related macular degeneration during antivascular endothelial growth factor (VEGF) treatment using optical coherence tomography angiography (OCTA) analysis.        Methods: Forty-one treatment-naïve...

Association Between Dome-shaped Macula and Posterior Staphyloma in Highly Myopic Eyes Investigated by Ultra-widefield Optical Coherence Tomography

Purpose: To investigate the relationship between dome-shaped maculas (DSMs) and posteriorstaphylomas in highly myopic eyes. Methods: Five hundred and eleven eyes of 291 patients with high myopia (refractive error ≤−8.0diopters or axial length ≥26.5 mm)...

Features of neovascularization in pachychoroid neovasculopathy compared with type 1 neovascular age-related macular degeneration on optical coherence tomography angiography

Purpose: To compare neovascular membrane features of pachychoroid neovasculopathy (PNV) and type 1 neovascular age-related macular degeneration (nAMD) using optical coherence tomography angiography (OCTA). Design: Retrospective study. Methods: We assessed 34 treatment-naïve eyes with a diagnosis of PNV and...

Optical coherence tomography of patients with Parkinson’s disease and progressive supranuclear palsy

Objectives: To determine if Parkinson's disease (PD) and progressive supranuclear palsy (PSP) differed on retinal measurements using optical coherence tomography (OCT). Patients and methods: In a prospective, controlled, cross-sectional cohort study, we recruited patients with PD or...

Carotid Disease and Retinal Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes: The Fremantle Diabetes Study Phase II

Objective: To use optical coherence tomography angiography (OCTA) to determine whether retinal microvascular parameters are associated with carotid arterial disease in people with type 2 diabetes. Research design and methods: Participants (community-based) underwent detailed assessments including carotid...

Spectral domain optical coherence tomography classification of diabetic macular edema: a new proposal to clinical practice

Purpose: To classify the types of diabetic macular edema (DME) and evaluate its morphological features on spectral domain optical coherence tomography (SD-OCT) and determine correlations between visual acuity and OCT findings. Methods: We assessed 406 eyes of...

Choroidal thickness changes after diabetes type 2 and blood pressure control in a hospitalized situation

Purpose: To investigate the effect of acute diabetic control on choroidal thickness in patients with Type 2 diabetes. Methods: Seventeen eyes of 17 patients with Type 2 diabetes were included in this prospective observational study. The patients...

Choroidal thickness change following vitrectomy in idiopathic epiretinal membrane and macular hole

Purpose: To investigate changes in choroidal thickness following vitrectomy in eyes with epiretinal membrane (ERM) and macular hole (MH) METHODS: Choroidal thicknesses at the fovea and at 1 and 3 mm superior, inferior, temporal, and...

Changes in Metamorphopsia and Optical Coherence Tomography Findings After Successful Retinal Detachment Surgery

Purpose: To investigate changes in metamorphopsia after rhegmatogenous retinal detachment surgery and to evaluate the relationship between metamorphopsia and retinal microstructures assessed with optical coherence tomography. Methods: The study included 47 eyes of 47 patients undergoing retinal...

Photoreceptor layer assessed in tissue layer image using spectral-domain optical coherence tomography after surgical closure of macular hole

Purpose: To investigate changes in the photoreceptor layer in tissue layer images using spectral-domain optical coherence tomography after macular hole surgery. Methods: Visual acuity and spectral-domain optical coherence tomography scans were obtained in 24 eyes with surgically...

Clinical manifestations of optic pit maculopathy as demonstrated by spectral domain optical coherence tomography

Purpose: The purpose of this retrospective study was to evaluate the characteristic features, including spectral-domain optical coherence tomography (SD-OCT), clinical course, and outcome of treatment if given for patients with optic disc pit maculopathy. Methods: We investigated...

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