Research

Differences in long-term progression of atrophy between neovascular and non-neovascular age-related macular degeneration

Purpose: To compare enlargement rates over 5 years of follow-up in geographic atrophy (GA) versus macular atrophy (MA) associated with macular neovascularization (MNV). Design:...

Efficacy of Half-Dose Photodynamic Therapy Versus High-Density Subthreshold Micropulse Laser for Treating Pigment Epithelial Detachments in Chronic Central Serous Chorioretinopathy

Purpose: Comparing the effect of half-dose photodynamic therapy and high-density subthreshold micropulse laser treatment on retinal pigment epithelial detachments (PEDs) in chronic central serous...

Predictors of Retinal Pigment Epithelium Tear Development After Treatment for Neovascular Age-Related Macular Degeneration Usıng Swept-Source Optical Coherence Tomography Angiography

Purpose: To investigate the predictors of retinal pigment epithelium (RPE) tear development after treatment for neovascular age-related macular degeneration (AMD) using swept-source optical coherence...

Hyperreflective foci as important prognostic indicators of progression of retınitis pigmentosa

Purpose: To investigate the presence and clinical relevance of hyperreflective foci (HRFs) in retinitis pigmentosa. Methods: Seventy seven retinitis pigmentosa cases were retrospectively reviewed. The 10-mm wide cross-line macular scans in optical coherence tomography were acquired. Hyperreflective...

Peripapillary pachychoroid syndrome: New Insights

Purpose: Available literature on peripapillary pachychoroid syndrome (PPS) is very limited. The purpose of this study is to evaluate features of PPS using multimodal imaging and shed further light on this entity. Methods: This is...

Correlation between focal choroidal excavation and underlying retinochoroidal disease: A pathological hypothesis from clinical observation

Purpose: To evaluate focal choroidal excavation (FCE) in eyes with various diseases using multimodal imaging modalities and to investigate the correlation of FCE and underlying chorioretinal diseases. Methods: This retrospective observational study included 62 eyes from...

Utilizatıon of Spectral Domain Optical Coherence Tomography to Identify Posterior Vitreous Detachment in Patients with Retinal Detachment

Purpose: To compare posterior vitreous detachment (PVD) identification rate between clinical examination versus spectral domain optical coherence tomography in patients with retinal detachment (RD). Methods: Data from the Primary Retinal Detachment Outcomes Study were used for this...

Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography

Objective: The aim of this study was to evaluate the perifoveal and peripapillary microvascular structure in patients with Behçet's disease (BD) without clinically ocular involvement. Methods: Fifty-six eyes of 28 patients with Behçet's disease without clinically ocular...

Evaluation of the Effects of Silicone Oil on the Macula with Optical Coherence Tomography in Patients with Rhegmatogenous Retinal Detachment

Objectives: The effects of silicone endotamponade duration on the macula were evaluated in patients with rhegmatogenous retinal detachment. Materials and Methods: Sixty-five eyes of 65 cases with rhegmatogenous retinal detachment that underwent pars plana vitrectomy...

Microcystic Macular Edema and Cystoid Macular Edema Before and After Epiretinal Membrane Surgery

Purpose: To investigate the types of intraretinal cysts (IRCs) that are associated with epiretinal membranes (ERMs) and to evaluate the effects of each type of IRC on postoperative outcomes. Methods: Retrospective, cross-sectional study design. Patients who underwent...

Evaluation of Retinal Vessel Diameters in Eyes With Active Central Serous Chorioretinopathy

Purpose: To compare the retinal vessel diameters of healthy eyes and active central serous chorioretinopathy (CSC) eyes, and to evaluate possible effect of retinal vessel diameter alterations on the pathogenesis of CSC. Methods: This retrospective...

Optical coherence tomography biomarkers for reduction of drusenoid pigment epithelium detachment

Purpose: To identify the optical coherence tomography biomarkers that can collectively predict the probability of collapse or reduction of drusenoid pigment epithelium detachment (PED). Methods: This consecutive observational case series reviewed the clinical data of 24 eyes...

The Pigtail Sign: A New OCT Finding After Inverted ILM Flap Surgery for Idiopathic Macular Hole

Purpose: To report a new spectral domain optical coherence tomography (OCT) finding called the pigtail sign. It was found during follow-up of idiopathic macular hole cases after inverted internal limiting membrane (ILM) flap surgery. Methods: This is...

Assessing the long-term evolution of type 3 neovascularization in age-related macular degeneration using optical coherence tomography angiography

Purpose:  To analyze the evolution of type 3 neovascularization in eyes with age-related macular degeneration during antivascular endothelial growth factor (VEGF) treatment using optical coherence tomography angiography (OCTA) analysis.        Methods: Forty-one treatment-naïve...

Association Between Dome-shaped Macula and Posterior Staphyloma in Highly Myopic Eyes Investigated by Ultra-widefield Optical Coherence Tomography

Purpose: To investigate the relationship between dome-shaped maculas (DSMs) and posteriorstaphylomas in highly myopic eyes. Methods: Five hundred and eleven eyes of 291 patients with high myopia (refractive error ≤−8.0diopters or axial length ≥26.5 mm)...

Features of neovascularization in pachychoroid neovasculopathy compared with type 1 neovascular age-related macular degeneration on optical coherence tomography angiography

Purpose: To compare neovascular membrane features of pachychoroid neovasculopathy (PNV) and type 1 neovascular age-related macular degeneration (nAMD) using optical coherence tomography angiography (OCTA). Design: Retrospective study. Methods: We assessed 34 treatment-naïve eyes with a diagnosis of PNV and...

Optical coherence tomography of patients with Parkinson’s disease and progressive supranuclear palsy

Objectives: To determine if Parkinson's disease (PD) and progressive supranuclear palsy (PSP) differed on retinal measurements using optical coherence tomography (OCT). Patients and methods: In a prospective, controlled, cross-sectional cohort study, we recruited patients with PD or...

Carotid Disease and Retinal Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes: The Fremantle Diabetes Study Phase II

Objective: To use optical coherence tomography angiography (OCTA) to determine whether retinal microvascular parameters are associated with carotid arterial disease in people with type 2 diabetes. Research design and methods: Participants (community-based) underwent detailed assessments including carotid...

Spectral domain optical coherence tomography classification of diabetic macular edema: a new proposal to clinical practice

Purpose: To classify the types of diabetic macular edema (DME) and evaluate its morphological features on spectral domain optical coherence tomography (SD-OCT) and determine correlations between visual acuity and OCT findings. Methods: We assessed 406 eyes of...

Choroidal thickness changes after diabetes type 2 and blood pressure control in a hospitalized situation

Purpose: To investigate the effect of acute diabetic control on choroidal thickness in patients with Type 2 diabetes. Methods: Seventeen eyes of 17 patients with Type 2 diabetes were included in this prospective observational study. The patients...

Choroidal thickness change following vitrectomy in idiopathic epiretinal membrane and macular hole

Purpose: To investigate changes in choroidal thickness following vitrectomy in eyes with epiretinal membrane (ERM) and macular hole (MH) METHODS: Choroidal thicknesses at the fovea and at 1 and 3 mm superior, inferior, temporal, and...

Changes in Metamorphopsia and Optical Coherence Tomography Findings After Successful Retinal Detachment Surgery

Purpose: To investigate changes in metamorphopsia after rhegmatogenous retinal detachment surgery and to evaluate the relationship between metamorphopsia and retinal microstructures assessed with optical coherence tomography. Methods: The study included 47 eyes of 47 patients undergoing retinal...

Photoreceptor layer assessed in tissue layer image using spectral-domain optical coherence tomography after surgical closure of macular hole

Purpose: To investigate changes in the photoreceptor layer in tissue layer images using spectral-domain optical coherence tomography after macular hole surgery. Methods: Visual acuity and spectral-domain optical coherence tomography scans were obtained in 24 eyes with surgically...

Clinical manifestations of optic pit maculopathy as demonstrated by spectral domain optical coherence tomography

Purpose: The purpose of this retrospective study was to evaluate the characteristic features, including spectral-domain optical coherence tomography (SD-OCT), clinical course, and outcome of treatment if given for patients with optic disc pit maculopathy. Methods: We investigated...

Evaluation of focal choroidal excavation in the macula using swept-source optical coherence tomography

Purpose: To evaluate imaging findings of patients with focal choroidal excavation (FCE) in the macula using swept-source optical coherence tomography (SS-OCT) and correlate it clinically. Methods: Prospective observational case series. Eleven consecutive patients (12 eyes) with FCE...

Optical Coherence Tomography Angiography in Retinal Vascular Diseases and Choroidal Neovascularization

Purpose: To assess the ability of optical coherence tomography-angiography (OCT-A) to show and analyze retinal vascular patterns and the choroidal neovascularization (CNV) in retinal vascular diseases.  Methods: Seven eyes of seven consecutive patients with retinal...

Pachychoroid Pigment Epitheliopathy Associated With Tamoxifen

Pachychoroid pigment epitheliopathy (PPE) is considered to be a forme fruste of central serous chorioretinopathy. Tamoxifen (Soltamax; Midatech Pharma, Raleigh, NC) has an anti-estrogenic effect on cytoplasmic estrogen receptors. Serum total testosterone, cortisol, and...

The effect of smoking on choroidal thickness measured by optical coherence tomography

Background/aims: To investigate the effect of smoking on choroidal thickness using Fourier domain optical coherence tomography. Methods: 17 otherwise healthy smokers (study group) and 17 non-smokers (control group) were enrolled. In the study group, all participants underwent...

Retinal pigment epithelium findings in patients with albinism using wide-field polarization-sensitive optical coherence tomography

Purpose: To investigate pigmentation characteristics of the retinal pigment epithelium (RPE) in patients with albinism using wide-field polarization-sensitive optical coherence tomography compared with intensity-based spectral domain optical coherence tomography and fundus autofluorescence imaging. Methods: Five patients (10...

Change of Retinal Nerve Layer Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy Revealed by Fourier Domain Optical Coherence Tomography

Purpose: To examine the changes of non-arteritic anterior ischemic optic neuropathy (NAION) by serial morphometry using Fourier domain optical coherence tomography (FD-OCT). Materials and methods: Retrospective study in patients with newly diagnosed NAION (n=33, all unilateral) and...

Correlation between morphological changes and functional outcomes of recent-onset macula-off rhegmatogenous retinal detachment: prognostic factors in rhegmatogenous retinal detachment

Purpose: To assess correlation between preoperative and postoperative findings and surgical factors, and postoperative functional outcomes after successful repair of acute macula-off rhegmatogenous retinal detachment (RRD). Methods: Forty-four eyes of 44 patients with recent-onset macula-off RRD who...

Diabetic macular morphology changes may occur in the early stage of diabetes

Background: The purpose of this study was to observe whether invisible morphological changes are presented in the two types of diabetes mellitus patients without diabetic retinopathy. Methods: Twenty-six type 1 diabetes mellitus (T1DM) patients and 34 type...

Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography

Purpose: To describe the pattern and magnitude of diurnal variation of choroidal thickness (CT), its relation to systemic and ocular factors, and to determine the intervisit reproducibility of diurnal patterns. Methods: A prospective study was conducted on...

Enhanced depth imaging optical coherence tomography of the choroid in central retinal vein occlusion

Purpose: To evaluate subfoveal choroidal thickness in patients with central retinal vein occlusion (CRVO) using enhanced depth imaging optical coherence tomography. Design: Retrospective observational study. Methods: We measured bilateral subfoveal choroidal thickness, averaged for 100 scans, in 36 patients...

Spectral-domain optical coherence tomography findings in polypoidal choroidal vasculopathy suggest a type 1 neovascular growth pattern

Purpose: To report spectral-domain optical coherence tomography (SD-OCT) findings in polypoidal choroidal vasculopathy (PCV). Patients and methods: Seventeen eyes of 15 consecutive patients diagnosed with PCV based on typical clinical and angiographic findings were imaged with macular...

Optical coherence tomography to monitor vigabatrin toxicity in children

Purpose: The antiepileptic drug vigabatrin is known to cause permanent loss of vision. Both visual field testing and electroretinogram are used to detect retinal damage. Adult data on optical coherence tomography (OCT) shows that retinal...

Outer Nuclear Layer Thinning in Pachychoroid Pigment Epitheliopathy

Purpose: To compare the average thicknesses of central inner retinal layers in eyes with pachychoroid pigment epitheliopathy (PPE), with uncomplicated pachychoroid (UCP), and of healthy subjects. Methods: Medical records of patients with PPE and UCP were retrospectively...

Effect of cataract surgery on optical coherence tomography measurements and repeatability in patients with non-insulin-dependent diabetes mellitus

Purpose: To evaluate the effect of uncomplicated cataract phacoemulsification on macular and retinal nerve fiber layer (RNFL) thickness using two spectral-domain optical coherence tomography (OCT) instruments, Cirrus OCT and Spectralis OCT, in patients having non-insulin-dependent...

OCT angiography in healthy human subjects

Background and objective: To noninvasively evaluate the retinal microvasculature in healthy human subjects with optical coherence tomography angiography (OCTA). Patients and methods: Cross-sectional, observational study of five healthy subjects. OCTA was performed on 3 × 3 mm(2)...

Exploring choriocapillaris under reticular pseudodrusen using OCT-Angiography

Purpose: To evaluate if choriocapillaris (CC) vessel density and CC decorrelation signal index are compromised in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCT-A). Methods: Decorrelation values in OCT-A CC images of 20 RPD...

Choroidal thickness in chronic rhegmatogenous retinal detachment before and after surgery, and comparison with acute cases

Purpose: To evaluate subfoveal choroidal thickness (SCT) in cases with chronic rhegmatogenous retinal detachment (RRD), before and after pars plana vitrectomy, and cases with acute RRD using optical coherence tomography. Methods: This retrospective study included 24 eyes...

External limiting membrane as a predictor of visual improvement in diabetic macular edema after pars plana vitrectomy

Background: To evaluate the predictors of visual improvement using spectral-domain optical coherence tomography (SD-OCT) in eyes with resistant diabetic macular edema (DME) treated with pars plana vitrectomy. Methods: Thirty-four eyes with resistant DME were evaluated in a...

Evaluation of the nerve fiber layer and macula in the eyes of healthy children using spectral-domain optical coherence tomography

Purpose: To determine the normative values of the peripapillary retinal nerve fiber layer (RNFL), macular thickness, and macular volume in healthy children using spectral-domain optical coherence tomography (SD-OCT) and analyze the correlation of such values...

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