Subretinal Fluid Associated with Drusenoid Pigment Epithelial Detachment

Purpose: To analyze the clinical characteristics of drusenoid pigment epithelial detachment (PED) with subretinal fluid (SRF) and to evaluate the impact of SRF on the long-term visual and anatomical outcomes.

Methods: Forty-seven eyes with drusenoid PED (47 patients) who completed more than 24 months follow-up were retrospectively analyzed. Intergroup comparisons of the visual and anatomical outcomes with and without SRF were made.

Results: The mean duration of follow-up was 32.9 ± 18.7 months. The group with drusenoid PED with SRF (14 eyes) showed significantly higher PED height (468 ± 130 µm vs. 313 ± 88 µm, P < 0.001), larger PED diameter (2328 ± 953 µm vs. 1227 ± 882 µm, P < 0.001), and larger PED volume (1.88 ± 1.73 mm3 vs. 1.12 ± 1.35 mm3, P = 0.021) than that in the group with drusenoid PED without SRF (33 eyes) at baseline. No significant intergroup difference was found regarding the best-corrected visual acuity at the final visit. In addition, the incidence of complete retinal pigment epithelial and outer retinal atrophy (cRORA; 21.4%) and the development of macular neovascularization (MNV; 7.1%) for the group with drusenoid PED with SRF showed no difference compared to those (39.4% for cRORA development and 9.1% for MNV development) with drusenoid PED without SRF.

Conclusion: The size, height, and volume of drusenoid PED were associated with the development of SRF. The SRF in drusenoid PED did not affect the visual prognosis or the development of macular atrophy during long-term follow-up.

Cho HJ, Jeon YJ, Yoon W, Lee J, Kim J, Kim CG, Kim JW. Subretinal Fluid associated with Drusenoid Pigment Epithelial Detachment. Retina 2023



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