Sharma and co-workers aimed to analyze the effect of fluid on visual acuity in cases of Type 3 macular neovascularization. This multicentric, retrospective cohort study included eyes with treatment-naïve Type 3 macular neovascularization. Analysis of fluid in different compartments was performed. Group A included eyes with isolated intraretinal fluid, whereas Group B included eyes with intraretinal fluid in conjunction with subretinal fluid and/or sub retinal pigment epithelial fluid. Sharma and co-workers cocluded that intraretinal fluid may be associated with good visual acuity in Type 3 macular neovascularization in contrast to other forms of neovascular age related macular degeneration. Furthermore, intraretinal fluid in isolation may need fewer injections and could probably be associated with less subfoveal atrophy.
Sharma A, Cheung CMG, Arias-Barquet L, et al. Fluid-based visual prognostication in Type 3 Macular Neovascularization-FLIP-3 Study. Retina. 2022;42:107-113. https://pubmed.ncbi.nlm.nih.gov/34255761/