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Best Disease Mimicking Central Serous Chorioretinopathy-September 2022


Thanks to everyone who showed interest in the section of question of the month and answered the question. In this month’s question, determine the diagnosis by looking OCT, IR images in a 32-year-old male patient was asked.

The answer to the question is ‘Best Disease Mimicking Central Serous Chorioretinopathy’. The result of the lottery among those who answered the question correctly, the winner of this month’s book prize is Sara Hemmati, MD. Congratulations to her.

Although the appearance of lipofuscin accumulation between the retinal pigment epithelium and the outer retina is characteristic of Best Disease, presence of hyperreflective material between the RPE and Bruch’s membrane, with serous macular detachment, may be the first presenting finding in some patients. The diagnosis may be controversial in such cases.

Sayman Muslubas I, Arf S, Hocaoglu M, Ersoz MG, Karacorlu M. Best Disease Presenting as Subretinal Pigment Epithelium Hyperreflective Lesion on Spectral-Domain Optical Coherence Tomography: Multimodal Imaging Features. Eur J Ophtalmol 2022 32(5):2702-2711.

 doi: 10.1177/11206721211055961.


Sara Hemmati, MD

Rasool Akram Hospital, Tehran, Iran

Dr. Sara Hemmati is graduated from Tehran University of Medical Science. She is currently working as ophthalmology resident at the Rasool Akram Hospital, Tehran, Iran.